Active Space Research Articles

Recruitment Strategies in the Integration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization Study (meSH): Multicenter Survey Study.

Hydroxyurea is an evidence-based disease-modifying therapy for sickle cell disease (SCD) but is underutilized. The Integration of Mobile Health into Sickle Cell Disease Care to Increase Hydroxyurea Utilization (meSH) multicenter study leveraged mHealth to deliver targeted interventions to patients and providers. SCD studies often underenroll; and recruitment strategies in the SCD population are not widely studied. Unanticipated events can negatively impact enrollment, making it important to study strategies that ensure adequate study accrual. The goal of this study was to evaluate enrollment barriers and the impact of modified recruitment strategies among patients and providers in the meSH study in response to a global emergency. Recruitment was anticipated to last 2 months for providers and 6 months for patients. The recruitment strategies used with patients and providers, new recruitment strategies, and recruitment rates were captured and compared. To document recruitment adaptations and their reasons, study staff responsible for recruitment completed an open-ended 9-item questionnaire eliciting challenges to recruitment and strategies used. Themes were extrapolated using thematic content analysis. Total enrollment across the 7 sites included 89 providers and 293 patients. The study acceptance rate was 85.5% (382/447) for both patients and providers. The reasons patients declined participation were most frequently a lack of time and interest in research, while providers mostly declined because of self-perceived high levels of SCD expertise, believing they did not need the intervention. Initially, recruitment involved an in-person invitation to participate during clinic visits (patients), staff meetings (providers), or within the office (providers). We identified several important recruitment challenges, including (1) lack of interest in research, (2) lack of human resources, (3) unavailable physical space for recruitment activities, and (4) lack of documentation to verify eligibility. Adaptive strategies were crucial to alleviate enrollment disruptions due to the COVID-19 pandemic. These included remote approaching and consenting (eg, telehealth, email, and telephone) for patients and providers. Additionally, for patients, recruitment was enriched by simplification of enrollment procedures (eg, directly approaching patients without a referral from the provider) and a multitouch method (ie, warm introductions with flyers, texts, and patient portal messages). We found that patient recruitment rates were similar between in-person and adapted (virtual with multitouch) approaches (167/200, 83.5% and 126/143, 88.1%, respectively; P=.23). However, for providers, recruitment was significantly higher for in-person vs remote recruitment (48/50, 96% and 41/54, 76%, respectively, P<.001). We found that timely adaptation in recruitment strategies secured high recruitment rates using an assortment of enriched remote recruitment strategies. Flexibility in approach and reducing the burden of enrollment procedures for participants aided enrollment. It is important to continue identifying effective recruitment strategies in studies involving patients with SCD and their providers and the impact and navigation of recruitment challenges. ClinicalTrials.Gov NCT03380351; https://clinicaltrials.gov/study/NCT03380351. RR2-10.2196/16319.

Promoting stress and anxiety recovery in older adults: assessing the therapeutic influence of biophilic green walls and outdoor view

Previous research has already provided evidence regarding the favorable impact of green walls and outdoor views on stress reduction and anxiety alleviation. However, there has been limited exploration into the combined effects of green walls and outdoor views on older adults. In this study, a between-subjects experiment was conducted using virtual reality (VR) technology with 23 participants. Following exposure to stressors, each participant underwent four randomized sessions, each lasting 5 min, in various virtual reality (VR) environments, encompassing non-biophilic and biophilic environments (including green walls, outdoor views, and their combination). Throughout the process, we measured physiological indicators of stress responses, including heart rate, heart rate variability, skin conductance levels, and blood pressure, using biometric sensors. Psychological changes in participants, including anxiety levels, were evaluated through the State–Trait Anxiety Inventory, recovery scales, and self-reported emotional assessments. In conclusion, in comparison to non-biophilic environments, older adults consistently exhibited lower stress levels, experienced superior anxiety relief, and demonstrated improved recovery in nature connectedness environments, with a notably faster recovery rate. These findings suggest that the incorporation of nature connectedness principles into the indoor environments of public activity spaces within older adults care facilities can significantly contribute to stress reduction and anxiety alleviation among older adults. Furthermore, these effects appear to be contingent on the specific types of nature connectedness environments. These results can provide substantial evidence to support the design of indoor common activity spaces within older adults care facilities.

Impact of Microclimate on Perception and Physical Activities in Public Spaces of New Urban Areas in Beijing, China

The development of new urban areas in Beijing has alleviated overcrowding in old urban centers and has ample public spaces for recreational activities. However, these public spaces are not ideally designed and have not been as successful as expected. Few studies have investigated the ineffective use of these public spaces in terms of microclimatic and thermal comfort factors. Our study investigated microclimatic factors, the subjective assessment of thermal comfort, the intensity of human activities, and the spatial features of public spaces in conjunction with surrounding buildings in a mixed commercial and residential complex in the Fangshan District, Beijing. We used a mixed-methods approach comprising microclimate measurements, questionnaires (n = 150), spatiotemporal behavior mapping, and field measurements. Our results showed that the human perception of the microclimate is related to the exposure duration and other microclimatic factors. The perception of people who spend longer periods outdoors is often inconsistent with objectively measured thermal comfort values. Activity intensity (low, medium, and high) was also related to the duration of time spent outdoors. Microclimatic factors affect the number of people at different activity intensities and the trajectory of the activities. Different spatial features cause different microclimate formations and can directly influence the human subjective assessment of thermal comfort. This study uniquely links the microclimate to human perceptions, physical activities, and spatial features in service of redesigning public spaces. We developed a comprehensive methodology that expands the post-occupancy evaluation and proposes new urban public space designs that consider microclimates. This study also provides a new perspective for promoting physical activity by enhancing the thermal comfort of the environment to achieve physical and mental health goals.

Ticks - public health risks in urban green spaces

BackgroundUrban green spaces are important for human health, but they may expose visitors to tick-borne diseases. This not only presents a potential public health challenge but also undermines the expected public health gains from urban green spaces. The aim of this study is to assess the public health risk of tick-borne diseases in an urban green space used for recreation in Stockholm, Sweden.MethodsWe used a mixed method approach identifying both the magnitude of the tick hazard and the extent of the human exposure to tick-borne diseases. At six entry points to an urban green space, we sampled ticks and documented microhabitat conditions from five randomly assigned 2 m × 2 m plots. Surrounding habitat data was analyzed using geographical information system (GIS). Nymphs and adult ticks were tested for Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum using TaqMan qPCR. Positive B. burgdorferi (s.l.) ticks were further analyzed by nested PCR amplification and sequence analysis. Population census data and visitor count data were used to estimate the degree of human exposure to tick-borne diseases. To further understand the degree to which visitors get in contact with infected ticks we also conducted interviews with visitors to green spaces.ResultsHigh tick densities were commonly found in humid broadleaved forest with low field vegetation. High pathogen prevalence was significantly correlated with increasing proportions of artificial areas. Integrating the tick hazard with human exposure we found that the public health risk of tick-borne diseases was moderate to high at most of the studied entry points. Many of the visitors frequently used urban green spaces. Walking was the most common activity, but visitors also engaged in activities with higher risk for tick encounters. Individual protective measures were connected to specific recreational activities such as picking berries or mushrooms.ConclusionsThe number of visitors can be combined with tick inventory data and molecular analyses of pathogen prevalence to make crude estimations of the public health risk of tick-borne diseases in urban green spaces. The risk of encountering infected ticks is omnipresent during recreational activities in urban green spaces, highlighting the need for public health campaigns to reduce the risk of tick-borne diseases.

Neighborhood violent crime exposure is associated with PrEP non-use among black sexually minoritized men and transgender women: A GPS Study.

The objective of this study is to use GPS technology to determine if violent and property crime exposure to participants activity spaces affect outcomes of the HIV prevention and care continuum (PCC) among Young Black sexually minoritized men (YBSMM) and Transgender women (TW), a subgroup at high vulnerability for new HIV diagnoses. Exposure to violent and property crime adversely affects a variety of acute and chronic medical conditions; however the relationship between exposure to violent and property crime and HIV risk (e.g., PrEP non use) is unknown. Spatial analytic analysis using dynamic Global Position Systems (GPS) technology can accurately detect geospatial associations between the crime exposure and objective HIV related outcomes. With the Neighborhoods and Networks (N2) Cohort Study, GPS technology to identify the activity space of 286 (123 PLWH and 163 PWoH) YBSMM & TW living in Chicago, IL, to identified spatial associations between violent and property crime exposures with HIV PCC outcomes. We found that YBSMM & TGW with higher exposure areas with higher levels of violent crime were less likely to use HIV preexposure prophylaxis (PrEP) therapy (aOR 0.76, 95% CI 0.63-0.91, p = 0.03). This study demonstrates the importance of clinical providers to consider violent crime as a potential sociostructural barrier that may impact medication adherence and health care outcomes among vulnerable populations. Additionally, GPS technology offers an alternative data analytic process that may be used to future studies to assist in identifying barriers to ending the HIV epidemic.

Potential-Energy Curves for the Ground and Several Electronic States of NdO and NdS.

Potential energy curves (PECs) were calculated for 21 and 18 electronic states of NdO and NdS molecules, respectively. In each case, static electron correlation effects were described by incomplete model space multiconfiguration self-consistent field wave functions based on an active space that included the most important valence orbitals. Dynamic electron correlation was included by the multireference second-order generalized Van Vleck perturbation theory method. Scalar-relativistic contributions were included by the effective core potential approach, using def2-TZVPP basis sets. Spin-dependent relativistic corrections were determined to be small and negligible for the Nd atom and so were not included in the calculations. The 21 and 18 electronic states of NdO and NdS were predicted to be in the excitation energy range of ∼3.2 and ∼2.7 eV, respectively. The ground electronic states of NdO and NdS were determined as 15H (6s4fσ4fϕ4fδ) and 15H (4fϕ4fπ4fπ6s), with spectroscopic constants: bond length Re = 1.780 and 2.325 Å, and harmonic frequency ωe = 891 and 538 cm-1, respectively.

Chinchero as Tourism Hub and Green Corridor as a Social Integrator in Cusco Peru 2023

This research focuses on the proposal of a corridor design that allows social and ecological integration in the context of a city with emerging potential as a tourist destination in Chinchero, Cusco. Key challenges addressed include lack of infrastructure to manage growing tourism demand, fragmentation of social identity, displacement of the local population due to gentrification processes, uncontrolled urban sprawl, and inappropriate exploitation of natural, cultural, and agricultural lands. To address these issues, a comprehensive diagnosis was carried out covering various urban-environmental dimensions, such as topography, road infrastructure, archeology, climate, and biodiversity. In this process, digital tools such as Blender, AutoCAD, Photoshop, and Affinity Designer were used. As a result of the analysis, an urban green corridor is proposed consisting of seven sectors covering the shores of the Piuray lagoon, the city center, and its archeological area, through the creation of socially active public spaces equipped with cultural, sports, and recreational facilities. The city of Chinchero, with its growing importance as a tourist destination, presents the opportunity and the need to develop a controlled urban development axis that promotes the connection between environmental, cultural, archeological, social, and tourism aspects. This objective is materialized in the form of a green corridor that seeks to promote social integration and a sense of territorial belonging.

How outdoor horticultural activities affect elderly adults' thermal, physiological and psychological responses: a field study.

We recruited 162 healthy elderly adults to determine the thermal, physiological, and psychological effects of horticultural activities (flower arranging, transplanting, and rubble masonry) in outdoor open spaces. We linked these to local climate conditions, physiology, and comfort through a questionnaire survey. The results showed that: (1) the neutral physiological equivalent temperature (NPET) before the horticultural activities were 22.18℃ for flower arranging, 23.67℃ for transplanting, and 20.78℃ for rubble masonry, while the NPET decreased to 18.53℃, 20.73℃ and 18.04℃ (respectively) after activities. (2) The heart rate and blood oxygen saturation changed significantly (p < 0.05) only after rubble masonry. (3) The average positive affect (PA) scores increased after flower arranging by 4.83, transplanting by 3.30, and rubble masonry by 4.00. (4) After activities, the thermal sensation vote was mainly influenced by globe temperature (41.36%), air temperature (33.47%), and wind speed (25.17%). Thermal comfort vote could be promoted because of 37.35% of an increasing positive and 21.20% of decreasing negative emotion.

A Foot in the Door: The Colonial Section of the German Foreign Office and the Settlement of Germans in Interwar Tanganyika

After 1925, German settlers began to return to the former German East Africa, lost through the Treaty of Versailles and transformed into the British Mandate of Tanganyika. The German Foreign Office's Colonial Section took on a proactive role to facilitate these Germans’ settlement in their former colony, including working with German ministries to release funding and navigating the British administration and settlers on the ground in Tanganyika. While Germany had lost its overseas colonies, these officials, many of whom had served in the pre-war empire, did not view their activity in colonial spaces like Tanganyika as belonging to the past. Officials in the Colonial Section navigated the appearance of political neutrality while also promoting their ‘colonial-political’ goals, hoping to create footholds of Germanness in Tanganyika that would keep open the possibility of future empire.

Game theory based finite-time formation control using artificial potentials for tethered space net robot

The Tethered Space Net Robot (TSNR) is an innovative solution for active space debris capture and removal. Its large envelope and simple capture method make it an attractive option for this task. However, capturing maneuverable debris with the flexible and elastic underactuated net poses significant challenges. To address this, a novel formation control method for the TSNR is proposed through the integration of differential game theory and robust adaptive control in this paper. Specifically, the trajectory of the TSNR is obtained through the solution of a real-time feedback pursuit-evasion game with a dynamic target, where the primary condition is to ensure the stability of the TSNR. Furthermore, to minimize tracking errors and maintain a specific configuration, a robust adaptive formation control scheme with Artificial Potential Field (APF) based on a Finite-Time Convergent Extended State Observer (FTCESO) is investigated. The proposed control method has a key advantage in suppressing complex oscillations by a new adaptive law, thus precisely maintaining the configuration. Finally, numerical simulations are performed to demonstrate the effectiveness of the proposed scheme.

메타버스 젭(ZEP)을 활용한 중학생의 그림책 하브루타 활동 경험에 관한 내러티브 탐구

Objectives The purpose of this study is to narratively explore middle school students' experiences and the meaning of their experiences through a havruta activity utilizing picture books within Metaverse Zeb.&#x0D; Methods This study used narrative inquiry to capture the healthy changes in participants' lives through the experience of Havruta activities in the Metaverse and to understand the context of each participant's life more holistically. Two secondary school students participated in 12 sessions of activities and in-depth individual interviews. 12 picture books, one for each session, were selected and categorized into person, home, and school areas based on spatiality and relationships. The research activity was conducted on the Metaverse platform Zeb for 12 sessions of 60 minutes per session. The main activities were question-based habvruta and argument- based havruta, which were conducted in the pair activity space.&#x0D; Results This study was more than just fun, it was a process of growth through psychological healing and problem solving. First, the participants improved their sense of psychological safety through accidental play and self-disclosure. Second, they recovered their “healing power” through support from their partner activities and family support. Third, they sought “problem-solving solutions” through understanding and acceptance of others and self-understanding and acceptance. Fourth, Study participants experienced a “self-growth process” in which I regained the power of healing, worked to solve problems, and searched for a changed future self.&#x0D; Conclusions By identifying the counseling value of havruta activities utilizing picture books in the Metaverse, this study will help lay the groundwork for the development of a virtual counseling program to support the development of young people who do not have access to face-to-face counseling.&#x0D;

Self-Consistent Field Approach for the Variational Quantum Eigensolver: Orbital Optimization Goes Adaptive.

We present a self-consistent field (SCF) approach within the adaptive derivative-assembled problem-tailored ansatz variational quantum eigensolver (ADAPT-VQE) framework for efficient quantum simulations of chemical systems on near-term quantum computers. To this end, our ADAPT-VQE-SCF approach combines the idea of generating an ansatz with a small number of parameters, resulting in shallow-depth quantum circuits with a direct minimization of an energy expression that is correct to second order with respect to changes in the molecular orbital basis. Our numerical analysis, including calculations for the transition-metal complex ferrocene [Fe (C5H5)2], indicates that convergence in the self-consistent orbital optimization loop can be reached without a considerable increase in the number of two-qubit gates in the quantum circuit by comparison to a VQE optimization in the initial molecular orbital basis. Moreover, the orbital optimization can be carried out simultaneously within each iteration of the ADAPT-VQE cycle. ADAPT-VQE-SCF thus allows us to implement a routine analogous to the complete active space SCF, a cornerstone of state-of-the-art computational chemistry, in a hardware-efficient manner on near-term quantum computers. Hence, ADAPT-VQE-SCF paves the way toward a paradigm shift for quantitative quantum-chemistry simulations on quantum computers by requiring fewer qubits and opening up for the use of large and flexible atomic orbital basis sets in contrast to earlier methods that are predominantly based on the idea of full active spaces with minimal basis sets.

Reframing Informal Institutional Voids as the Attempted Remaking of Contested Social Spaces: Evidence from England

The conventional perspective on institutional voids as mere absences has recently faced criticism. Recent research suggests that voids are instead sites of contestation between institutions. However, understanding the specifics of this and how informal voids function in such contestations requires deeper investigation. We combine insights from the institutional voids and political theory literatures to reconceptualise informal voids as spaces of attempted institutional remaking which occurs through three key activities - developing new norms, devising legitimate political interventions and negotiating new rules. We present data from 123 interviews to demonstrate these three activities. This evidence enables us to challenge two assumptions in the voids literature and to demonstrate how an informal void (as reconceptualised) functions at the nexus of health and urban development in England. This study has implications for investigating informal voids as active social spaces, where actors attempt to remake contested social spaces through three core types of activity.

Examining the directionality of mobility patterns in activity spaces: Introducing the ‘mobility snowflake’ visual analytic and measurement framework

Activity spaces characterise an individual's mobility patterns and provide critical insights important to a broad suite of applications. Emergent forms of disaggregate space-time data offer new opportunities to exploit a more granular approach to measuring and visualising activity spaces. Drawing on individual GPS trajectories for 365 participants covering a seven-day period the current paper presents a new measurement and visualisation framework examining the directionality of mobility patterns. This framework moves beyond existing work that measures activity spaces via a simple geometric shape (traditionally a convex hull) to introduce a new metric and associated visual analytic capturing a new dimension of the concept. Results have important consequences for policy and planning, with the hope that the framework can be redeployed across various situational and cultural contexts, leading to the creation of an expanding collection of comparative studies.

Synergistic oxidation of toluene through bimetal/cordierite monolithic catalysts with ozone

Toluene treatment has received extensive attention, and ozone synergistic catalytic oxidation was thought to be a potential method to degrade VOCs (violate organic compounds) due to its low reaction temperature and high catalytic efficiency. A series of bimetal/Cord monolithic catalysts were prepared by impregnation with cordierite, including MnxCu5−x/Cord, MnxCo5−x/Cord and CuxCo5−x/Cord (x = 1, 2, 3, 4). Analysis of textural properties, structures and morphology characteristics on the prepared catalysts were conducted to evaluate their performance on toluene conversion. Effects of active component ratio, ozone addition and space velocity on the catalytic oxidation of toluene were investigated. Results showed that MnxCo5−x/Cord was the best among the three bimetal catalysts, and toluene conversion and mineralization rates reached 100 and 96% under the condition of Mn2Co3/Cord with 3.0 g/m3 O3 at the space velocity of 12,000 h−1. Ozone addition in the catalytic oxidation of toluene by MnxCo5−x/Cord could efficiently avoid the 40% reduction of the specific surface area of catalysts, because it could lower the optimal temperature from 300 to 100 °C. (Co/Mn)(Co/Mn)2O4 diffraction peaks in XRD spectra indicated all the four MnxCo1−x/Cord catalysts had a spinel structure, and diffraction peak intensity of spinel reached the largest at the ratio of Mn:Co = 2:3. Toluene conversion rate increased with rising ozone concentration because intermediate products generated by toluene degradation might react with excess ozone to generate free radicals like ·OH, which would improve the toluene mineralization rate of Mn2Co3/Cord catalyst. This study would provide a theoretical support for its industrial application.

New physical insights into the supporting subspace factorization of XMS-CASPT2 and generalization to multiple spin states via spin-free formulation.

This paper introduces a spin-free formulation of the supporting subspace factorization [C. Song and T. J. Martínez, J. Chem. Phys. 149, 044108 (2018)], enabling a reduction in the computational scaling of the extended multi-state complete active space second-order perturbation (XMS-CASPT2) method for arbitrary spins. Compared to the original formulation that is defined in the spin orbitals and is limited to singlet states, the spin-free formulation in this work treats different spin states equivalently, thus naturally generalizing the idea beyond singlet states. In addition, we will present a new way of deriving the supporting subspace factorization with the purpose of understanding its physical interpretation. In this new derivation, we separate the sources that make CASPT2 difficult into the "same-site interactions" and "inter-site interactions." We will first show how the Kronecker sum can be used to remove the same-site interactions in the absence of inter-site interactions, leading to MP2 energy in dressed orbitals. We will then show how the inter-site interactions can be exactly recovered using Löwdin partition, where the supporting subspace concept will naturally arise. The new spin-free formulation maintains the main advantage of the supporting subspace factorization, i.e., allowing XMS-CASPT2 energies to be computed using highly optimized MP2 energy codes and Fock build codes, thus reducing the scaling of XMS-CASPT2 to the same scaling as MP2. We will present and discuss results that benchmark the accuracy and performance of the new method. To demonstrate how the new method can be useful in studying real photochemical systems, the supporting subspace XMS-CASPT2 is applied to a photoreaction sensitive to magnetic field effects. The new spin-free formulation makes it possible to calculate the doublet and quartet states required in this particular photoreaction mechanism.

A CASSCF/MRCI trajectory surface hopping simulation of the photochemical dynamics and the gas phase ultrafast electron diffraction patterns of cyclobutanone.

We present the simulation of the photochemical dynamics of cyclobutanone induced by the excitation of the 3s Rydberg state. For this purpose, we apply the complete active space self-consistent field method together with the spin-orbit multireference configuration interaction singles treatment, combined with the trajectory surface hopping for the inclusion of nonadiabatic effects. The simulations were performed in the spin-adiabatic representation, including nine electronic states derived from three singlet and two triplet spin-diabatic states. Our simulations reproduce the two previously observed primary dissociation channels: the C2 pathway yielding C2H4 + CH2CO and the C3 pathway producing c-C3H6 + CO. In addition, two secondary products, CH2 + CO from the C2 pathway and C3H6 from the C3 pathway, both of them previously reported, are also observed in our simulation. We determine the ratio of the C3:C2 products to be about 2.8. Our findings show that most of the trajectories reach their electronic ground state within 200fs, with dissociation events finished after 300fs. We also identify the minimum energy conical intersections that are responsible for the relaxation and provide an analysis of the photochemical reaction mechanism based on multidimensional scaling. Furthermore, we demonstrate a minimal impact of triplet states on the photodissociation mechanism within the observed timescale. In order to provide a direct link to experiments, we simulate the gas phase ultrafast electron diffraction patterns and connect their features to the underlying structural dynamics.

Revolution as a transition from empire to nation-state(s): Comparing the Soviet and Chinese paths

How did revolutions facilitate empires’ transition to nation-states? This article compares the Bolshevik and the Chinese Communist Revolutions. It conceptualizes this Soviet–Sino comparison through three dimensions of nation-building: separating from a universal community, building a national cultural core and overcoming internal ethnopolitics. Both socialist regimes accommodated the nation-state model by fusing centralized control with limited autonomy for ethnic minorities. Yet, whereas the Soviet Union claimed to be a universal union of nation-states, which was supposed to keep accepting new members until it covered the entire globe, the People’s Republic of China resembled a typical nation-state that preserved multiethnicity and enclosed borders under the title of the ‘Chinese Nation’. In analyzing the influence of revolutions, this article probes three relations: inter-revolution, revolution–society and revolution–counterrevolution. Arising after the Bolsheviks as a follower-revolution, the Chinese Communist Party (CCP) was confined to a national component of the USSR’s global communism project. This shaped the CCP’s enclosed geographical activity space, Han-dominated ethnic composition and the consciousness of national liberation. The CCP’s mobilization covered far wider social strata than the Bolsheviks’ had, which engendered stronger manpower and motivation to transform the traditional culture into a national culture. Being weak at its borderlands, the CCP was cautious about the doctrine of ‘national self-determination’, not daring to make it a geopolitical weapon for revolution export as the Bolsheviks had done in founding the Soviet Union. Owing to each of these differences in revolutionary trajectories, the CCP was more receptive to ‘China’ than the Bolsheviks were to ‘Russia’, and this led to two distinctive ways of reorganizing empires into nation-states.

Representational maps in the brain: concepts, approaches, and applications.

Neural systems have evolved to process sensory stimuli in a way that allows for efficient and adaptive behavior in a complex environment. Recent technological advances enable us to investigate sensory processing in animal models by simultaneously recording the activity of large populations of neurons with single-cell resolution, yielding high-dimensional datasets. In this review, we discuss concepts and approaches for assessing the population-level representation of sensory stimuli in the form of a representational map. In such a map, not only are the identities of stimuli distinctly represented, but their relational similarity is also mapped onto the space of neuronal activity. We highlight example studies in which the structure of representational maps in the brain are estimated from recordings in humans as well as animals and compare their methodological approaches. Finally, we integrate these aspects and provide an outlook for how the concept of representational maps could be applied to various fields in basic and clinical neuroscience.

Disruptive, dangerous, and dirty: active travel measures as a ‘cause’ of car-related externalities

Automobility centred on private car use generates various externalities – or ‘antagonisms’ – that threaten its sustainability as a mobility regime. Through expanding the practice and spaces of driving, mass immobility can result. With increased car use, comes increased energy use, generating an ecological antagonism for this regime. Finally, greater car use has resulted in mass road traffic injuries and fatalities, which presents another threat to the growth and maintenance of this unique form of automobility. While these antagonisms present a risk, they have also been leveraged as a means to establish and secure the dominance of automobility. As part of a wider study exploring discourses of opposition to redistributive active travel measures in Dún Laoghaire-Rathdown, Ireland, this paper illustrates how active travel measures that present a challenge to automobility are depicted as disruptive, dangerous and dirty. These measures, precisely designed to mitigate the antagonisms of mass car use, are construed instead as primary causes of these systemic externalities. This study thereby reveals how active travel spaces themselves – and spatial regulations that favour active travellers – can be unfavourably represented as a means of politically sustaining automobility.